Cytarabine (Cytosine Arabinoside)

  is a pyrimidine nucleoside analog.

  Cytarabine is a cell-phase-specific cytotoxic drug, primarily during the S phase when cells are undergoing DNA synthesis.

  It is used for treatment of hematological malignancies.



ECG changes that may be observed in patients under Cytarabine therapy

  Bradycardia.

  Negative T waves.

  Electrocardiographic evidence of pericarditis.



References

  Anatol J Cardiol 2013;13(6):618-619.

  J Cardiol Cases 2013;8(3):105-107.

  Eur J Cancer Care (Engl) 2009;18(3):320-1.

  Leuk Lymphoma 2007;48(6):1247-1249.

  Leuk Res 1995;19(2):141-144.

  Oncol Res Treat 2014;37(9):487-490.

  Expert Opin Pharmacother 2017;18(16):1765-1780.




ECG 1. The ECG above belongs to a 23 years-old woman with acute myeloid leukemia (AML).
It was recorded after Cytarabine therapy. Sinus bradycardia is seen.

Hematologist Assoc. Prof. Dr. Ender Soydan has donated the above ECG to our website.

Click here for a more detailed ECG