Last update: April 2020


Loperamide

  is an antidiarrheal agent.

  is an opioid receptor agonist.

  may cause cardiotoxicity due to blockade of Na and IKr channels.



Loperamide toxicity may cause ECG abnormalities

  Wide QRS tachycardia

  Severe bradycardia

  QT interval prolongation

  Brugada phenocopy

  Diffuse T wave negativity

  Polymorphic ventricular tachycardia



References

  J Cardiovasc Electrophysiol 2019;30:2618-2626.

  Am J Ther 2018;25:e548-e550.

  J Emerg Med 2018;54:484-486.

  Am J Emerg Med 2018;36:1716.e1-1716.e3.

  J Am Board Fam Med 2017;30:832-834.

  Clin Toxicol (Phila) 2017;55:659-661.